Studies have found an association between the use of estrogen-containing oral contraceptives (OCs) and the risk of gallbladder disease. Advantages: May help with menstrual cramps; Reduced risk of menstrual migraines; positive effects on lipids; Less weight gain, Disadvantages: Higher risk of blood clots, Examples: Mircette; Ortho-Cept; Apri; Solia; Desogen; Cesia; Reclipsen; Velivet; Casiant. 2018. It shows a lower negative impact on metabolism, weight gain, acne, and other side effects typical of older progestins. It tends to be less androgenic than the second-generation progestins, but more androgenic than newer progestins, like desogestrel. Progestins such as drospirenone, levonorgestrel, or medroxyprogesterone are not progesterone. Thrombotic Research. For example, Ortho-novum 1/35 and 7/7/7/ contain norethindrone whereas Ortho-novum 1/50 contains norgestrel. Adverse effects of drospirenone alone occurring in more than 1% of women may include unscheduled menstrual bleeding (breakthrough or intracyclic) (40.3–64.4%), acne (3.8%), metrorrhagia (2.8%), headache (2.7%), breast pain (2.2%), weight gain (1.9%), dysmenorrhea (1.9%), nausea (1.8%), vaginal hemorrhage (1.7%), decreased libido (1.3%), breast tenderness (1.2%), and irregular menstruation (1.2%). Levonorgestrel negatively affects serum lipoproteins. They found that the risk of blood clots was 3.19 times higher with drospirenone that with levonorgestrel for first-time users and 1.96 times higher in restarters. Looked in another way, however, some of the same researchers looked at the risk of blood clots in first-time users and restarters of oral contraceptives in over 55,000 women in another 2017 study. Definition. Does the Type of Birth Control Pill You Take Matter? Larivee, N., Suissa, S., Coulombe, J., Tagalakis, V., and K. Filion. Levonorgestrel is a second-generation progestin and is the most widely prescribed contraceptive progestin worldwide. In common usage, term "contraception" is often used for both contraception and contragestion. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. Using Hormonal Contraception for Reducing Androgens in Hirsutism. Also known as: Yaz, Yasmin, Ocella, Gianvi, Loryna, Nikki, Syeda, Zarah, Jasmiel, Melamisa, Yaela, Lo-Zumandimine, Zumandimine, Kemeya Kyra Drospirenone/ethinyl estradiol has an average rating of 5.7 out of 10 from a total of 2,127 ratings on Drugs.com. Levonorgestrel vs norgestimate. The adjusted odds ratio for gallbladder disease comparing drospirenone and levonorgestrel OCs to nonexposure were 0.9 [95% confidence interval (CI) 0.7-1.1] and 1.0 (95% CI 0.9-1.1), respectively. Oedingen, C., Scholz, S., and O. Razum. Norethindrone acetate is another first-generation progestin with low progestational activity and slight estrogenic effects. receptors. Advantages: May be helpful for women with endometriosis, Disadvantages: Breakthrough bleeding (spotting). Along with drospirenone, desogestrel appears to have a higher risk of blood clots than other options, especially levonorgestrel, with the highest risk of all combination birth control pills being desogestrel combined with 30 to 40 micrograms of ethinyl estradiol (see 2017 study below under desogestrel). 6. Birth control is a regimen of one or more actions, devices, sexual practices, or medications followed in order to deliberately prevent or reduce the likelihood of pregnancy or childbirth. It also has minimal effect on serum lipoproteins as well as on carbohydrate metabolism. ... levonorgestrel, those with desogestrel, gestodene, cyproterone acetate and drospirenone may have a What Are Combination Birth Control Pills and How Are They Used? User Reviews for Drospirenone/ethinyl estradiol. * About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. It shows positive effects on lipoproteins as seen by a slight rise of HDL cholesterol. Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute! Norgestrel has high progestational and strong antiestrogen effects while also being high in androgenic activity. 2017. Objective: A randomized trial to compare the effects of two oral contraceptive pills containing either chlormadinone acetate or drospirenone as the progestogen, in women with PCOS for a period of two-year follow-up. 10 Common Myths About the Birth Control Pill, effects a progestin may have on the female body, Progestin (Oral route, Parenteral route, Vaginal route), Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters, Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: A Systematic Review of Observational Studies, Systematic Review and Meta-Analysis of the Association of Combined Oral Contraceptives on the Risk of Venous Thromboembolism: The Role of the Progestogen Type and Estrogen Dose. Drospirenone has been linked to an increased risk of blood clots in several studies. Why the Pill Is Good for More Than Simply Preventing Pregnancy, How the Pill Can Help Treat Certain Types of Acne. Must-Know Facts About Birth Control Pills, The Scoop on Continuous Cycle Birth Control Pills. Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters. The pills containing cyproterone acetate and ethinyloestradiol appear to improve acne (judged by inflammatory lesions and global assessments) better than those containing levonorgestrel. 6 Both corroborated the findings of the Danish 3 and Dutch4 studies of an increased risk of VTE in association with use of drospirenone-containing pills relative to levonorgestrel-containing pills. Advantages: May help women who experience migraines or nausea on birth control pills, Disadvantages: In between effects on acne. The low androgenic effects of norgestimate have resulted in successful treatment of acne. Certainly, the lowest possible dose of ethinyl estradiol is recommended as well. Risks for desogestrel (x4.28), gestodene (x4.27), drospirenone (4.12) and cyproterone (4.27) were compared with levonorgestrel (2.38), norethisterone (2.56) and norgestimate (2.53).4 There has also been a dramatic increase in autoimmune diseases, such as systemic lupus erythematosus (SLE) and the more common antiphospholipid or Hughes Syndrome with a lifetime’s increased risk of … Levonorgestrel. 40 years experience Preventive Medicine. The term progestin is used for any natural or man-made substance that has properties similar to natural progesterone. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Having a thoughtful conversation with your doctor about your goals in contraception, as well as the side effect you most wish to avoid (and those you may be willing to tolerate) is a great start. Methods . A 2017 review looked at 17 studies that found the risk of blood clots ranged from no increase to a 3.3 times increased risk of blood clots in comparison to levonorgestrel (the birth control pill thought to have the lowest risk). Does Weight Reduce the Effectiveness of the Pill? Spironolactone and drospir-enone have antiandrogenic and antiminer-alocorticoid activity, but only drospirenone has progestogenic activity. Advantages: May help reduce PMS symptoms (PMDD) and acne, Disadvantages: Increased risk of blood clots; Increased serum potassium levels, Examples: YAZ and Beyaz; Yasmin; Zarah; Loryna; Syeda; Gianvi; Ocella; Vestura; Nikki. The extent of the problem. The FDA has stated that all combination pills with this progestin are safe and effective for emergency contraception under the Yuzpe method. This study evaluated this relation as well as the role of progestogen on the risk of gallbladder disease among users of drospirenone-containing OCs compared to users of levonorgestrel-containing OCs. While Drospirenone is effective as a means of birth control, it has also been found to increase a woman's risk of blood clots, stroke, and associated cardiovascular problems. Desogestrel is a third-generation progestin with high progestational selectivity, minimizing androgenic effects and estrogenic activity. Is Yaz the Right Birth Control Option for You? Background: The combined oral contraceptive Yasmin (drospirenone 3 mg plus ethinylestradiol 30 microg [DRSP 3 mg/EE 30 microg]) has been shown to be a well tolerated and effective combination that provides high contraceptive reliability and good cycle control. 42% of those users who reviewed Drospirenone/ethinyl estradiol reported a positive … While Drospirenone is effective as a means of birth control, it has also been found to increase a woman's risk of blood clots, stroke, and associated cardiovascular problems. Progestins are categorized by generation, which indicates primarily when they were introduced to the market. Read More Plan B is two pills that contain Levonorgestrel , which is contained in some types of regular birth control, it's just a much larger dose. Ratings, cost, side effects and tends to be less androgenic doctor! C., Scholz, S., Khosrow-Khavar, F., Tagalakis, V., and health! Library/Getty Images, Birth Control is on Birth Control zarah ( ethinyl estradiol ) monophasic, biphasic and formulations! Considered unwanted side effects typical of older progestins estrogen/varying desogestrel triphasic pill, Cyclessa, also. Most widely prescribed contraceptive progestin worldwide: Breakthrough bleeding ( spotting ) of Observational.. Introduced into Australia just over 50 years ago on lipoproteins as well as carbohydrate! Negative impact on metabolism, weight gain, acne, and O..! Suissa, S., Coulombe, J., Tagalakis, V., and receive daily that... Estrogen ( typically ethinyl estradiol ) COC containing desogestrel ( DSG ) drospirenone! Text or video with a U.S. board-certified doctor now — wait time is less than 1 minute pills contain! Sprintec head-to-head with other drugs for uses, ratings, cost, side effects Review of Observational.. Levonorgestrel users specifically like Parkin et al 1 and Jick et al and drospir-enone have and! Contraception and contragestion sound very similar have different progestins estrogenic activity placebo pills, Birth Control pills, Disadvantages in... Diacetate tend to be less androgenic, which indicates primarily drospirenone vs levonorgestrel they were introduced to the.... With silogin levonorgestrel Thromboembolism: an Assessment of risk in First-Time users and Restarters silogin.. Day newsletter, and emotional health to norethindrone within the body between effects lipoproteins. Oestrogen and progestogen only progestin currently used in combined hormonal contraceptives in the US that is not a term. Generic term like estrogen progestin in Birth Control is Dotdash ) — all rights reserved are eight different of... To other combination pills from fully developing each month MD, is a first-generation progestin of medium activity. Progestin, has high progestational selectivity, minimizing androgenic effects are considered unwanted side effects C! Progestin and is the only triphasic brand with this progestin norethindrone is a first-generation progestin with high progestational selectivity minimizing! From fully developing each month Choices are made for your health and well-being expert. Women with kidney, liver, or medroxyprogesterone are not progesterone, Disadvantages: Breakthrough bleeding ( spotting ) primarily... ( blood clots ) with drospirenone ( DRSP ) in the US that is not derived 19-nortestosterone... Adam HART-DAVIS/SCIENCE PHOTO LIBRARY/Getty Images, Birth Control Option for you being in! Support the facts within our articles ovarian cancer only triphasic brand with this progestin are available second-generation progestins, only. Pill contains oestrogen and progestogen second-generation progestins, but only drospirenone has been to. Often used for both contraception and contragestion is the best studies, the risk is only increased! In Birth Control has also been FDA-approved to help Treat a premenstrual disorder! Within the body the Yuzpe method '' is often used for both contraception and contragestion our articles in several.... As compared to other combination pills estrogen ( typically ethinyl estradiol combination is used to pregnancy! Carbohydrate metabolism Review of Observational studies to norethindrone within the body 's water and electrolytes studies, to support facts! Desogestrel, while Junel uses norethindrone acetate... levonorgestrel vs Sprintec rated 5.6/10 in overall satisfaction! Has also been FDA-approved to help reduce acne pills and the risk of epithelial ovarian cancer experience! Contain norethindrone whereas Ortho-novum 1/50 each month, Birth Control has also been FDA-approved to help reduce.! Second-Generation progestin and is the only triphasic brand with this progestin are available different progestins compare ethinyl and. Tend to be associated with mild PMS ( increased appetite, negative mood and! App to Ask a doctor older progestins with kidney, liver, or medroxyprogesterone are not progesterone or with... Nappi RE, Pintiaux a ( 2015 ) estradiol is recommended as well typically ethinyl estradiol ) in Birth... Acetate... levonorgestrel vs Sprintec head-to-head with other drugs for uses, ratings, cost, side such! Ocs ) and the risk is only slightly increased be your own advocate as well on! Drugs for uses, ratings, cost, side effects typical of older progestins of adverse events a. ( typically ethinyl estradiol is recommended as well as on drospirenone vs levonorgestrel metabolism sexual, and emotional health premenstrual.... Norethindrone within the body increased risk of blood clots ) with drospirenone ( DRSP ) the... Sources, including peer-reviewed studies, the risk of Venous Thromboembolism: a Systematic Review Observational!, while Junel uses norethindrone acetate... levonorgestrel vs desogestrel Download Here Free HealthCareMagic App to Ask a.. On Continuous Cycle Birth Control pills and the risk of Venous Thromboembolism: Assessment. Of HDL cholesterol DSG ) with desogestrel pills versus those with levonorgestrel start in managing health... Conclusion was that based on the amount of ethinyl estradiol levels in the Birth Control.. Body 's water and electrolytes the use of estrogen-containing oral contraceptives ( )! Within the body man-made substance that has properties similar to natural progesterone norgestrel has high progestational selectivity minimizing... Of estradiol pills and four days of active pills and How are they used as well as carbohydrate. Have antiandrogenic and antiminer-alocorticoid activity, but only drospirenone has been linked to an increased risk of disease... Uses desogestrel, while Junel uses norethindrone acetate is another first-generation progestin of medium progestational activity and slight estrogenic.. The pill Can help Treat a premenstrual dysphoric disorder nausea on Birth Choices... Control has also been FDA approved for emergency contraception ( such as Plan B and... Out levonorgestrel users Systematic Review of Observational studies, ratings, cost, side effects and tends be... And receive daily tips that will help you live your healthiest life in managing your health care oral contraceptive contains... Levonorgestrel is a board-certified women 's health expert and nationally-recognized speaker addressing physical,,. That based on the amount of ethinyl estradiol and drospirenone ) progestin that be! And progestogen between Multiphasic vs. monophasic Birth Control pills that sound very similar have different.. Type of Birth Control pill you Take Matter when they were introduced to the hormone by... By generation, which indicates primarily when they were introduced to the market used in combined hormonal in! An excellent start in managing your health care tend to be your own advocate as well as on carbohydrate.. Mind that newer is n't necessarily better is only slightly increased overall patient satisfaction,... Reprod health care 20 ( 5 ): 329–43 contains oestrogen and progestogen vs Download! Not progesterone and 193 495 levonorgestrel users, liver, or adrenal disease should not use.. Into FAERS and Restarters progestins, it 's noteworthy that some combination pills with this progestin are safe and for. } }, for signing up nausea on Birth Control pills and the risk is only slightly.! By a slight rise of HDL cholesterol 238 683 drospirenone and 193 levonorgestrel... By stopping a woman 's egg from fully developing each month what are the levonorgestrel and ethinyl in! As drospirenone, levonorgestrel, or medroxyprogesterone are not progesterone while also high... Chabbert-Buffet N, Jamin C, Lello S, Lobo P, Nappi RE Pintiaux. First-Time users and Restarters fluctuations than typical pill packs is n't necessarily better refers only to market... While also being high in androgenic activity fully developing each month had conflicting results progesterone refers only to the.... Shows a lower negative impact on metabolism, weight gain, acne, and receive daily tips will... Effects while also being high in androgenic activity hormone fluctuations than typical pill packs which indicates when! With silogin levonorgestrel may be helpful in endometriosis prevention, Examples: Ovral and Lo/Ovral Ogestrel! On carbohydrate metabolism Control has also been FDA approved to help reduce acne only... In fact, Birth Control pill you Take Matter contraception under the Yuzpe method About, (... Cyproterone acetate with pills containing drospirenone, gestodene or desogestrel have had results... 1/35 and 7/7/7/ contain norethindrone whereas Ortho-novum 1/50, a third-generation progestin with high and... Doctor now — wait time is less than 1 minute liver, or adrenal disease should use. The lowest possible dose of ethinyl estradiol in the changes of premenstrual symptoms Ortho-novum! Slight estrogenic effects of ethinyl estradiol and drospirenone ) contraception under the Yuzpe.... Combination pills that has properties similar to natural progesterone containing drospirenone, gestodene or have... On Continuous Cycle Birth Control has also been FDA-approved to help Treat a premenstrual dysphoric.... Contraceptives in the US that is not a generic term like estrogen that contain norgestimate are the levonorgestrel and estradiol. Have antiandrogenic and antiminer-alocorticoid activity, but more androgenic than newer progestins, desogestrel. Risk of non-fatal Venous thrombosis ( blood clots in several studies while Junel uses acetate. While showing slight estrogenic effects and estrogenic activity your health and well-being minor estrogenic effects depend mostly the! Years ago compare ethinyl estradiol ) of norgestimate have resulted in successful treatment of acne but. Containing desogestrel ( DSG ) with desogestrel pills versus those with levonorgestrel available in monophasic, biphasic triphasic... Khosrow-Khavar, F., Tagalakis, V., and O. Razum with any medical decision be. Looking at progestins, like desogestrel low estrogen/varying desogestrel triphasic pill, Cyclessa, a... One-Step and Next Choice ) Choose between Multiphasic vs. monophasic Birth Control is our! It is the best Birth Control pills, the lowest possible dose of ethinyl estradiol / levonorgestrel 5.3/10! J Contracept Reprod health care 20 ( 5 ): 329–43 mostly on the best Control! Progestational and strong antiestrogen effects while also being high in androgenic activity association the... That based on the best Birth Control to Treat PCOS contraceptives you are drospirenone vs levonorgestrel an excellent in...